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UniProt functional annotation for Q3V3R1 | ||
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| UniProt code: Q3V3R1. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000269|PubMed:15611115}. |
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| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10- formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57453, ChEBI:CHEBI:57454, ChEBI:CHEBI:456216; EC=6.3.4.3; |
| Pathway: | |
One-carbon metabolism; tetrahydrofolate interconversion. |
| Subunit: | |
Homodimer. {ECO:0000250}. |
| Subcellular location: | |
Mitochondrion {ECO:0000250}. |
| Domain: | |
This monofunctional enzyme consists of two major domains: an N- terminal inactive methylene-THF dehydrogenase and cyclohydrolase domain and an active larger formyl-THF synthetase C-terminal domain. |
| Similarity: | |
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. {ECO:0000305}. |
| Similarity: | |
In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAH30437.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.