PDBsum entry 2dk3

Protein binding

PDB id: 2dk3

Contents

Protein chain

86 a.a. *

* Residue conservation analysis

PDB id:

2dk3

Name:

Protein binding

Title:

Solution structure of mib-herc2 domain in hect domain containing protein 1

Structure:

E3 ubiquitin-protein ligase hectd1. Chain: a. Fragment: mib-herc2 domain. Synonym: hect domain-containing protein 1, e3 ligase for inhibin receptor, eulir. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hectd1, kiaa1131. Expressed in: cell free synthesis. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

F.He,Y.Muto,M.Inoue,T.Kigawa,M.Shirouzu,T.Terada,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

F.He et al. Solution structure of mib-Herc2 domain in hect domain containing protein 1. To be published, .

Date:

06-Apr-06 Release date: 06-Oct-06

Protein chain

Q9ULT8  (HECD1_HUMAN) -  E3 ubiquitin-protein ligase HECTD1 from Homo sapiens

Seq: 2610 a.a.

Struc: 86 a.a.*

* PDB and UniProt seqs differ at 13 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.26 - HECT-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine