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UniProt functional annotation for Q9ULT8 | ||
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| UniProt code: Q9ULT8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys- 63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. {ECO:0000250|UniProtKB:Q69ZR2}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence={ECO:0000250|UniProtKB:Q69ZR2}; |
| Pathway: | |
Protein modification; protein ubiquitination. |
| Subunit: | |
Interacts with IGSF1 (PubMed:12421765). Interacts (via N- terminus) with HSP90AA1 (By similarity). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:12421765}. |
| Similarity: | |
Belongs to the UPL family. K-HECT subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.