PDBsum entry 2dig

DNA binding protein

PDB id: 2dig

Contents

Protein chain

68 a.a. *

* Residue conservation analysis

PDB id:

2dig

Name:

DNA binding protein

Title:

Solusion structure of the todor domain of human lamin-b receptor

Structure:

Lamin-b receptor. Chain: a. Fragment: tudor domain. Synonym: integral nuclear envelope inner membrane protein, lmn2r. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: lbr. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

M.Yoneyama,N.Tochio,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

M.Yoneyama et al. Solusion structure of the todor domain of human lamin-B receptor. To be published, .

Date:

30-Mar-06 Release date: 30-Sep-06

Protein chain

Q14739  (LBR_HUMAN) -  Delta(14)-sterol reductase LBR from Homo sapiens

Seq: 615 a.a.

Struc: 68 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.1.3.1.70 - Delta(14)-sterol reductase.
• Pathway: Sterol ring B, C, D modification
• Reaction: 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP⁺ = 4,4-dimethyl- 5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site