EC 1.3.1.70 - Δ14-sterol reductase

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IntEnz Enzyme Nomenclature
EC 1.3.1.70

Names

Accepted name:
Δ14-sterol reductase
Other names:
sterol C14-reductase
C-14 sterol reductase
Systematic name:
4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol:NADP+ Δ14-oxidoreductase

Reaction

Comments:

This enzyme acts on a range of steroids with a 14(15)-double bond.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050613
CAS Registry Number: 69403-07-2
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Bottema, C.K. and Parks, L.W.
    Δ14-Sterol reductase in Saccharomyces cerevisiae.
    Biochim. Biophys. Acta 531: 301-307 (1978). [PMID: 32908]
  2. Paik, Y.K., Trzaskos, J.M., Shafice, A. and Gaylor, J.L.
    Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent Δ8,14-steroid 14-reductase.
    J. Biol. Chem. 259: 13413-13423 (1984). [PMID: 6444198]

[EC 1.3.1.70 created 2001]