PDBsum entry 1whb

Hydrolase

PDB id: 1whb

Contents

Protein chain

157 a.a. *

* Residue conservation analysis

PDB id:

1whb

Name:

Hydrolase

Title:

Solution structure of the rhodanese-like domain in human ubiquitin specific protease 8 (ubp8)

Structure:

Kiaa0055. Chain: a. Fragment: rhodanese-like domain. Synonym: ubiquitin specific protease 8, ubp8. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa cdna ha01049. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

K.Saito,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

K.Saito et al. Solution structure of the rhodanese-Like domain in human ubiquitin specific protease 8 (ubp8). To be published, .

Date:

28-May-04 Release date: 28-Nov-04

Protein chain

P40818  (UBP8_HUMAN) -  Ubiquitin carboxyl-terminal hydrolase 8 from Homo sapiens

Seq: 1118 a.a.

Struc: 157 a.a.*

* PDB and UniProt seqs differ at 10 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.19.12 - ubiquitinyl hydrolase 1.
• Reaction: Thiol-dependent hydrolysis of ester, thiolester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).