PDBsum entry 1vt2

Ribosome

PDB id: 1vt2

Contents

Protein chains

271 a.a. *

209 a.a. *

201 a.a. *

178 a.a. *

176 a.a. *

149 a.a. *

141 a.a. *

142 a.a. *

122 a.a. *

143 a.a. *

136 a.a. *

120 a.a. *

116 a.a. *

114 a.a. *

117 a.a. *

103 a.a. *

110 a.a. *

93 a.a. *

102 a.a. *

94 a.a. *

79 a.a. *

77 a.a. *

63 a.a. *

58 a.a. *

56 a.a. *

50 a.a. *

46 a.a. *

64 a.a. *

38 a.a. *

DNA/RNA

Metals

_MG ×137

_ZN

Waters ×643

* Residue conservation analysis

Obsolete entry

PDB id:

1vt2

Name:

Ribosome

Title:

Crystal structure of the e. Coli ribosome bound to cem-101. This file contains the 50s subunit of the second 70s ribosome.

Structure:

23s rrna. Chain: a. 5s rrna. Chain: b. 50s ribosomal protein l2. Chain: c. 50s ribosomal protein l3. Chain: d. 50s ribosomal protein l4.

Source:

Escherichia coli. Organism_taxid: 562. Organism_taxid: 83333. Strain: k-12. Strain: k-12

Resolution:

3.30Å R-factor: 0.188 R-free: 0.244

Authors:

J.A.Dunkle,W.Zhang,J.H.D.Cate,A.S.Mankin

Key ref:

B.Llano-Sotelo et al. (2010). Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob Agents Chemother, 54, 4961-4970. PubMed id: 20855725

Date:

06-Sep-10 Release date: 06-Oct-10

Protein chain

P60422  (RL2_ECOLI) -  50S ribosomal protein L2 from Escherichia coli (strain K12)

Seq: 273 a.a.

Struc: 271 a.a.

Protein chain

P60438  (RL3_ECOLI) -  50S ribosomal protein L3 from Escherichia coli (strain K12)

Seq: 209 a.a.

Struc: 209 a.a.

Protein chain

P60723  (RL4_ECOLI) -  50S ribosomal protein L4 from Escherichia coli (strain K12)

Seq: 201 a.a.

Struc: 201 a.a.

Protein chain

P62399  (RL5_ECOLI) -  50S ribosomal protein L5 from Escherichia coli (strain K12)

Seq: 179 a.a.

Struc: 178 a.a.

Protein chain

P0AG55  (RL6_ECOLI) -  50S ribosomal protein L6 from Escherichia coli (strain K12)

Seq: 177 a.a.

Struc: 176 a.a.

Protein chain

P0A7R1  (RL9_ECOLI) -  50S ribosomal protein L9 from Escherichia coli (strain K12)

Seq: 149 a.a.

Struc: 149 a.a.

Protein chain

P0A7J7  (RL11_ECOLI) -  50S ribosomal protein L11 from Escherichia coli (strain K12)

Seq: 142 a.a.

Struc: 141 a.a.

Protein chain

P0AA10  (RL13_ECOLI) -  50S ribosomal protein L13 from Escherichia coli (strain K12)

Seq: 142 a.a.

Struc: 142 a.a.

Protein chain

P0ADY3  (RL14_ECOLI) -  50S ribosomal protein L14 from Escherichia coli (strain K12)

Seq: 123 a.a.

Struc: 122 a.a.

Protein chain

P02413  (RL15_ECOLI) -  50S ribosomal protein L15 from Escherichia coli (strain K12)

Seq: 144 a.a.

Struc: 143 a.a.

Protein chain

P0ADY7  (RL16_ECOLI) -  50S ribosomal protein L16 from Escherichia coli (strain K12)

Seq: 136 a.a.

Struc: 136 a.a.

Protein chain

P0AG44  (RL17_ECOLI) -  50S ribosomal protein L17 from Escherichia coli (strain K12)

Seq: 127 a.a.

Struc: 120 a.a.

Protein chain

P0C018  (RL18_ECOLI) -  50S ribosomal protein L18 from Escherichia coli (strain K12)

Seq: 117 a.a.

Struc: 116 a.a.

Protein chain

P0A7K6  (RL19_ECOLI) -  50S ribosomal protein L19 from Escherichia coli (strain K12)

Seq: 115 a.a.

Struc: 114 a.a.

Protein chain

P0A7L3  (RL20_ECOLI) -  50S ribosomal protein L20 from Escherichia coli (strain K12)

Seq: 118 a.a.

Struc: 117 a.a.

Protein chain

P0AG48  (RL21_ECOLI) -  50S ribosomal protein L21 from Escherichia coli (strain K12)

Seq: 103 a.a.

Struc: 103 a.a.

Protein chain

P61175  (RL22_ECOLI) -  50S ribosomal protein L22 from Escherichia coli (strain K12)

Seq: 110 a.a.

Struc: 110 a.a.

Protein chain

P0ADZ0  (RL23_ECOLI) -  50S ribosomal protein L23 from Escherichia coli (strain K12)

Seq: 100 a.a.

Struc: 93 a.a.

Protein chain

P60624  (RL24_ECOLI) -  50S ribosomal protein L24 from Escherichia coli (strain K12)

Seq: 104 a.a.

Struc: 102 a.a.

Protein chain

P68919  (RL25_ECOLI) -  50S ribosomal protein L25 from Escherichia coli (strain K12)

Seq: 94 a.a.

Struc: 94 a.a.

Protein chain

P0A7L8  (RL27_ECOLI) -  50S ribosomal protein L27 from Escherichia coli (strain K12)

Seq: 85 a.a.

Struc: 79 a.a.

Protein chain

P0A7M2  (RL28_ECOLI) -  50S ribosomal protein L28 from Escherichia coli (strain K12)

Seq: 78 a.a.

Struc: 77 a.a.

Protein chain

P0A7M6  (RL29_ECOLI) -  50S ribosomal protein L29 from Escherichia coli (strain K12)

Seq: 63 a.a.

Struc: 63 a.a.

Protein chain

P0AG51  (RL30_ECOLI) -  50S ribosomal protein L30 from Escherichia coli (strain K12)

Seq: 59 a.a.

Struc: 58 a.a.

Protein chain

P0A7N4  (RL32_ECOLI) -  50S ribosomal protein L32 from Escherichia coli (strain K12)

Seq: 57 a.a.

Struc: 56 a.a.

Protein chain

P0A7N9  (RL33_ECOLI) -  50S ribosomal protein L33 from Escherichia coli (strain K12)

Seq: 55 a.a.

Struc: 50 a.a.

Protein chain

P0A7P5  (RL34_ECOLI) -  50S ribosomal protein L34 from Escherichia coli (strain K12)

Seq: 46 a.a.

Struc: 46 a.a.

Protein chain

P0A7Q1  (RL35_ECOLI) -  50S ribosomal protein L35 from Escherichia coli (strain K12)

Seq: 65 a.a.

Struc: 64 a.a.

Protein chain

P0A7Q6  (RL36_ECOLI) -  50S ribosomal protein L36 from Escherichia coli (strain K12)

Seq: 38 a.a.

Struc: 38 a.a.

DNA/RNA chains

G-G-U-U-A-A-G-C-G-A-C-U-A-A-G-C-G-U-A-C-A-C-G-G-U-G-G-A-U-G-C-C-C-U-G-G-C-A-G- ... 2841 bases

G-C-C-U-G-G-C-G-G-C-C-G-U-A-G-C-G-C-G-G-U-G-G-U-C-C-C-A-C-C-U-G-A-C-C-C-C-A-U- 117 bases

Antimicrob Agents Chemother 54:4961-4970 (2010)

PubMed id: 20855725

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.

B.Llano-Sotelo, J.Dunkle, D.Klepacki, W.Zhang, P.Fernandes, J.H.Cate, A.S.Mankin.

ABSTRACT

No abstract given.