PDBsum entry 1vce

Transferase

PDB id: 1vce

Contents

Protein chains

265 a.a. *

Ligands

SAH

Waters ×478

* Residue conservation analysis

PDB id:

1vce

Name:

Transferase

Title:

Crystal structure of project id ph0725 from pyrococcus horikoshii ot3

Structure:

Diphthine synthase. Chain: a, b. Engineered: yes

Source:

Pyrococcus horikoshii. Organism_taxid: 70601. Strain: ot3. Gene: ph0725. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Dimer (from PQS)

Resolution:

2.10Å R-factor: 0.218 R-free: 0.253

Authors:

N.Kunishima,K.Shimizu,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

N.Kunishima and k.shimizu Crystal structure of diphthine synthase from pyrococcus horikoshii ot3. To be published, .

Date:

07-Mar-04 Release date: 29-Mar-05

Protein chains

O58456  (DPHB_PYRHO) -  Diphthine synthase from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)

Seq: 265 a.a.

Struc: 265 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.98 - diphthine synthase.
• Reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H⁺

2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 × S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 × S-adenosyl-L-homocysteine + 3 × H(+) (Bound ligand (Het Group name = SAH) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site