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PDBsum entry 1lhs
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Oxygen storage
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PDB id
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1lhs
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxygen storage
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Title:
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Loggerhead sea turtle myoglobin (aquo-met)
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Structure:
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Myoglobin. Chain: a. Engineered: yes
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Source:
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Caretta caretta. Loggerhead turtle. Organism_taxid: 8467
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Resolution:
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Authors:
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M.Nardini,C.Tarricone,A.Lania,A.Desideri,G.De Sanctis,M.Coletta, R.Petruzzelli,P.Ascenzi,A.Coda,M.Bolognesi
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Key ref:
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M.Nardini
et al.
(1995).
Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolution.
J Mol Biol,
247,
459-465.
PubMed id:
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Date:
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01-Feb-95
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Release date:
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03-Jun-95
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PROCHECK
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Headers
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References
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P56208
(MYG_CARCR) -
Myoglobin from Caretta caretta
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Seq:
Struc:
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154 a.a.
153 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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J Mol Biol
247:459-465
(1995)
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PubMed id:
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Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolution.
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M.Nardini,
C.Tarricone,
M.Rizzi,
A.Lania,
A.Desideri,
G.De Sanctis,
M.Coletta,
R.Petruzzelli,
P.Ascenzi,
A.Coda.
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ABSTRACT
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The X-ray crystal structures of the aquo-met and cyano-met derivatives of the
loggerhead sea turtle (Caretta caretta) myoglobin have been determined at 2.0 A
resolution (R = 0.182, and 0.178, respectively). The results here reported,
representing the first reptile globin solved by X-ray crystallography, have been
analyzed in parallel with data for related monomeric hemoproteins, and indicate
a strong overall structural similarity between the loggerhead sea turtle and
mammalian myoglobins, reflected by the 63% amino acid identity of their primary
structures. The root-mean-square deviation between the entire polypeptide
backbones of loggerhead sea turtle and sperm whale myoglobins, after structure
superposition, is 0.83 A. Upon cyanide binding to the protein distal site, the
iron-bound water molecule present in the aquo-met form is displaced by the
incoming ligand. Cyanide is oriented towards the inner part of the heme distal
site forming a Fe-C-N angle of 133 degrees.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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A.Bolli,
C.Ciaccio,
M.Coletta,
M.Nardini,
M.Bolognesi,
A.Pesce,
M.Guertin,
P.Visca,
and
P.Ascenzi
(2008).
Ferrous Campylobacter jejuni truncated hemoglobin P displays an extremely high reactivity for cyanide - a comparative study.
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FEBS J,
275,
633-645.
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M.Sugishima,
K.Oda,
T.Ogura,
H.Sakamoto,
M.Noguchi,
and
K.Fukuyama
(2007).
Alternative cyanide-binding modes to the haem iron in haem oxygenase.
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Acta Crystallogr Sect F Struct Biol Cryst Commun,
63,
471-474.
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PDB code:
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V.de Serrano,
Z.Chen,
M.F.Davis,
and
S.Franzen
(2007).
X-ray crystal structural analysis of the binding site in the ferric and oxyferrous forms of the recombinant heme dehaloperoxidase cloned from Amphitrite ornata.
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Acta Crystallogr D Biol Crystallogr,
63,
1094-1101.
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PDB codes:
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D.D.Castelli,
E.Lovera,
P.Ascenzi,
and
M.Fasano
(2002).
Unfolding of the loggerhead sea turtle (Caretta caretta) myoglobin: A (1)H-NMR and electronic absorbance study.
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Protein Sci,
11,
2273-2278.
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M.Bolognesi,
C.Rosano,
R.Losso,
A.Borassi,
M.Rizzi,
J.B.Wittenberg,
A.Boffi,
and
P.Ascenzi
(1999).
Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an x-ray crystallographic study.
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Biophys J,
77,
1093-1099.
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PDB codes:
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S.Aime,
M.Fasano,
S.Paoletti,
F.Cutruzzolà,
A.Desideri,
M.Bolognesi,
M.Rizzi,
and
P.Ascenzi
(1996).
Structural determinants of fluoride and formate binding to hemoglobin and myoglobin: crystallographic and 1H-NMR relaxometric study.
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Biophys J,
70,
482-488.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
