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PDBsum entry 1lhs
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Oxygen storage
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PDB id
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1lhs
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References listed in PDB file
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Key reference
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Title
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Reptile heme protein structure: X-Ray crystallographic study of the aquo-Met and cyano-Met derivatives of the loggerhead sea turtle (caretta caretta) myoglobin at 2.0 a resolution.
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Authors
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M.Nardini,
C.Tarricone,
M.Rizzi,
A.Lania,
A.Desideri,
G.De sanctis,
M.Coletta,
R.Petruzzelli,
P.Ascenzi,
A.Coda.
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Ref.
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J Mol Biol, 1995,
247,
459-465.
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PubMed id
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Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
percentage match of
95%.
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Abstract
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The X-ray crystal structures of the aquo-met and cyano-met derivatives of the
loggerhead sea turtle (Caretta caretta) myoglobin have been determined at 2.0 A
resolution (R = 0.182, and 0.178, respectively). The results here reported,
representing the first reptile globin solved by X-ray crystallography, have been
analyzed in parallel with data for related monomeric hemoproteins, and indicate
a strong overall structural similarity between the loggerhead sea turtle and
mammalian myoglobins, reflected by the 63% amino acid identity of their primary
structures. The root-mean-square deviation between the entire polypeptide
backbones of loggerhead sea turtle and sperm whale myoglobins, after structure
superposition, is 0.83 A. Upon cyanide binding to the protein distal site, the
iron-bound water molecule present in the aquo-met form is displaced by the
incoming ligand. Cyanide is oriented towards the inner part of the heme distal
site forming a Fe-C-N angle of 133 degrees.
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Secondary reference #1
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Title
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X-Ray crystal structure of ferric aplysia limacina myoglobin in different liganded states.
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Authors
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E.Conti,
C.Moser,
M.Rizzi,
A.Mattevi,
C.Lionetti,
A.Coda,
P.Ascenzi,
M.Brunori,
M.Bolognesi.
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Ref.
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J Mol Biol, 1993,
233,
498-508.
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PubMed id
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Secondary reference #2
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Title
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Structural studies on the loggerhead sea turtle (caretta caretta) myoglobin.
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Authors
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R.Petruzzelli,
G.Aureli,
E.Casale,
M.Nardini,
M.Rizzi,
P.Ascenzi,
M.Coletta,
G.De sanctis,
A.Desideri,
A.Galtieri.
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Ref.
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Biochem Mol Biol Int, 1993,
31,
19-24.
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PubMed id
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