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PDBsum entry 1avc
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Calcium/phospholipid-binding protein
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PDB id
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1avc
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Calcium/phospholipid-binding protein
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Title:
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Bovine annexin vi (calcium-bound)
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Structure:
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Annexin vi. Chain: a. Synonym: p68, protein iii, 67-kda-calcimedin, lipocortin vi, 67-kda- calelectrin, chromobindin 20, calphobindin ii
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Source:
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Bos taurus. Cattle. Organism_taxid: 9913. Organ: liver. Cellular_location: membrane-peripheral
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Resolution:
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2.90Å
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R-factor:
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0.205
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R-free:
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0.268
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Authors:
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A.J.Avila-Sakar,C.E.Creutz,R.H.Kretsinger
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Key ref:
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A.J.Avila-Sakar
et al.
(1998).
Crystal structure of bovine annexin VI in a calcium-bound state.
Biochim Biophys Acta,
1387,
103-116.
PubMed id:
DOI:
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Date:
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16-Sep-97
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Release date:
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28-Jan-98
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PROCHECK
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Headers
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References
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P79134
(ANXA6_BOVIN) -
Annexin A6 from Bos taurus
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Seq:
Struc:
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673 a.a.
642 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 8 residue positions (black
crosses)
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DOI no:
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Biochim Biophys Acta
1387:103-116
(1998)
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PubMed id:
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Crystal structure of bovine annexin VI in a calcium-bound state.
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A.J.Avila-Sakar,
C.E.Creutz,
R.H.Kretsinger.
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ABSTRACT
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The crystal structure of a calcium-bound form of bovine annexin VI has been
determined with X-ray diffraction data to 2.9 A by molecular replacement. Six
Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB,
which binds calcium, and V-AB, which does not) have conformations that differ
significantly from those in calcium-free, human recombinant annexin VI. There
are only small differences between the calci- and the apo-annexin VI in the rest
of the molecule. Calcium by itself does not promote a major conformational
change.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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C.Enrich,
C.Rentero,
S.V.de Muga,
M.Reverter,
V.Mulay,
P.Wood,
M.Koese,
and
T.Grewal
(2011).
Annexin A6-Linking Ca(2+) signaling with cholesterol transport.
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Biochim Biophys Acta,
1813,
935-947.
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A.C.Rintala-Dempsey,
A.Rezvanpour,
and
G.S.Shaw
(2008).
S100-annexin complexes--structural insights.
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FEBS J,
275,
4956-4966.
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B.R.Genge,
L.N.Wu,
and
R.E.Wuthier
(2007).
In vitro modeling of matrix vesicle nucleation: synergistic stimulation of mineral formation by annexin A5 and phosphatidylserine.
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J Biol Chem,
282,
26035-26045.
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P.Pathuri,
E.T.Nguyen,
S.G.Svärd,
and
H.Luecke
(2007).
Apo and calcium-bound crystal structures of Alpha-11 giardin, an unusual annexin from Giardia lamblia.
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J Mol Biol,
368,
493-508.
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PDB codes:
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T.Fischer,
L.Lu,
H.T.Haigler,
and
R.Langen
(2007).
Annexin B12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes.
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J Biol Chem,
282,
9996.
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D.G.Naidu,
A.Raha,
X.L.Chen,
A.R.Spitzer,
and
A.Chander
(2005).
Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7.
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Biochim Biophys Acta,
1734,
152-168.
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V.Gerke,
C.E.Creutz,
and
S.E.Moss
(2005).
Annexins: linking Ca2+ signalling to membrane dynamics.
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Nat Rev Mol Cell Biol,
6,
449-461.
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A.Korostelev,
M.O.Fenley,
and
M.S.Chapman
(2004).
Impact of a Poisson-Boltzmann electrostatic restraint on protein structures refined at medium resolution.
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Acta Crystallogr D Biol Crystallogr,
60,
1786-1794.
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M.Golczak,
A.Kirilenko,
J.Bandorowicz-Pikula,
B.Desbat,
and
S.Pikula
(2004).
Structure of human annexin a6 at the air-water interface and in a membrane-bound state.
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Biophys J,
87,
1215-1226.
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Y.Mo,
B.Campos,
T.R.Mealy,
L.Commodore,
J.F.Head,
J.R.Dedman,
and
B.A.Seaton
(2003).
Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces.
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J Biol Chem,
278,
2437-2443.
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PDB codes:
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A.Kirilenko,
M.Golczak,
S.Pikula,
R.Buchet,
and
J.Bandorowicz-Pikula
(2002).
GTP-induced membrane binding and ion channel activity of annexin VI: is annexin VI a GTP biosensor?
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Biophys J,
82,
2737-2745.
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F.Fabiola,
R.Bertram,
A.Korostelev,
and
M.S.Chapman
(2002).
An improved hydrogen bond potential: impact on medium resolution protein structures.
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Protein Sci,
11,
1415-1423.
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I.de Diego,
F.Schwartz,
H.Siegfried,
P.Dauterstedt,
J.Heeren,
U.Beisiegel,
C.Enrich,
and
T.Grewal
(2002).
Cholesterol modulates the membrane binding and intracellular distribution of annexin 6.
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J Biol Chem,
277,
32187-32194.
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P.Montaville,
J.M.Neumann,
F.Russo-Marie,
F.Ochsenbein,
and
A.Sanson
(2002).
A new consensus sequence for phosphatidylserine recognition by annexins.
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J Biol Chem,
277,
24684-24693.
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M.Danieluk,
S.Pikuła,
and
J.Bandorowicz-Pikuła
(1999).
Annexin VI interacts with adenine nucleotides and their analogs.
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Biochimie,
81,
717-726.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
