PDBsum entry 1avc

Calcium/phospholipid-binding protein

PDB id: 1avc

Contents

Protein chain

642 a.a.

Metals

_CA ×6

Waters ×117

References listed in PDB file

Key reference

• Title: Crystal structure of bovine annexin vi in a calcium-Bound state.
• Authors: A.J.Avila-Sakar, C.E.Creutz, R.H.Kretsinger.
• Ref.: Biochim Biophys Acta, 1998, 1387, 103-116. [DOI no: 10.1016/S0167-4838(98)00111-3]
• PubMed id: 9748523

Note In the PDB file this reference is annotated as "TO BE PUBLISHED". The citation details given above were identified by an automated search of PubMed on title and author names, giving a perfect match.

Abstract

The crystal structure of a calcium-bound form of bovine annexin VI has been determined with X-ray diffraction data to 2.9 A by molecular replacement. Six Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB, which binds calcium, and V-AB, which does not) have conformations that differ significantly from those in calcium-free, human recombinant annexin VI. There are only small differences between the calci- and the apo-annexin VI in the rest of the molecule. Calcium by itself does not promote a major conformational change.

Secondary reference #1

• Title: The crystal structure of annexin VI indicates relative rotation of the two lobes upon membrane binding.
• Authors: H.Kawasaki, A.Avila-Sakar, C.E.Creutz, R.H.Kretsinger.
• Ref.: Biochim Biophys Acta, 1996, 1313, 277-282. [DOI no: 10.1016/0167-4889(96)00100-0]
• PubMed id: 8898865