› 8t1c

Electron Microscopy
3.49Å resolution

Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA

Released:
DOI: 10.2210/pdb8t1c/pdb
PDB entry 8t1c coloured by chain, front view.
PDB entry 8t1c coloured by chain, side view.
PDB entry 8t1c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human TRPV4 in complex with GTPase RhoA.
Nadezhdin KD, Talyzina IA, Parthasarathy A, Neuberger A, Zhang DX, Sobolevsky AI
OpenAccess logo Nat Commun 14 3733 (2023)
PMID: 37353478
Related structures: EMD-40959

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-237041 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transient receptor potential cation channel subfamily V member 4 Chain: A
Molecule details ›
Chain: A
Length: 1132 amino acids
Theoretical weight: 127.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HBA0 (Residues: 1-871; Coverage: 100%)
Gene names: TRPV4, VRL2, VROAC
Sequence domains:
Transforming protein RhoA Chain: E
Molecule details ›
Chain: E
Length: 193 amino acids
Theoretical weight: 21.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61586 (Residues: 1-193; Coverage: 100%)
Gene names: ARH12, ARHA, RHO12, RHOA
Sequence domains: Ras family

Ligands and Environments

1 bound ligand:
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.49Å
Relevant EMDB volumes: EMD-40959
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer.
Otero-Sobrino et al. (2023)
1 other article