› 8d9y

X-ray diffraction
2.2Å resolution

Crystal structure of Taipan alpha-neurotoxin in complex with Centi-3FTX-D09 antibody

Released:
DOI: 10.2210/pdb8d9y/pdb
PDB entry 8d9y coloured by chain, front view.
PDB entry 8d9y coloured by chain, side view.
PDB entry 8d9y coloured by chain, top view.
Source organisms:
Entry authors: Pletnev S, Verardi R, Tully ES, Glanville J, Kwong PD

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224716 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Centi-3FTX-D09 Fab light chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 214 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Centi-3FTX-D09 Fab heavy chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 237 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Long neurotoxin 1 Chains: I, J, K, L
Molecule details ›
Chains: I, J, K, L
Length: 71 amino acids
Theoretical weight: 7.91 KDa
Source organism: Oxyuranus scutellatus scutellatus
Expression system: Homo sapiens
UniProt:
  • Canonical: A8HDK9 (Residues: 22-92; Coverage: 100%)
Sequence domains: u-PAR/Ly-6 domain

Ligands and Environments

4 bound ligands:
Ligand EPE 1 x EPE
Ligand PG6 1 x PG6
Ligand PG4 1 x PG4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 77.808Å b: 87.228Å c: 101.302Å
α: 109.29° β: 104.26° γ: 106.48°
R-values:
R R work R free
0.21 0.209 0.262
Expression system: Homo sapiens

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