› 8a0u

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional enhancer factor TEF-5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 222 amino acids
Theoretical weight: 25.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q99594 (Residues: 218-435; Coverage: 50%)
Gene names: TEAD3, TEAD5, TEF5
Sequence domains: YAP binding domain

Ligands and Environments

3 bound ligands:
Ligand MYR 4 x MYR
Ligand KMU 4 x KMU
Ligand PO4 8 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 65.265Å b: 128.607Å c: 156.107Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.268
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

1 review citation

Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis.
Thrash et al. (2023)
5 other articles

1 mention without citation

Leveraging Hot Spots of TEAD-Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling.
Zhao et al. (2023)