› 8ah5

X-ray diffraction
1.25Å resolution

Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P212121 at pH 4.6

Released:
DOI: 10.2210/pdb8ah5/pdb
PDB entry 8ah5 coloured by chain, front view.
PDB entry 8ah5 coloured by chain, side view.
PDB entry 8ah5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions
Salinas-Garcia MC, Plaza-Garrido M, Gavira JA, Murciano-Calles J, Andujar-Sanchez M, Ortiz-Salmeron E, Martinez JC, Camara-Artigas A
Crystals (2023)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160251 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4 Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78352 (Residues: 302-403; Coverage: 14%)
Gene names: DLG4, PSD95
Sequence domains: PDZ domain

Ligands and Environments

1 bound ligand:
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 28.845Å b: 32.344Å c: 88.305Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.15 0.148 0.185
Expression system: Escherichia coli BL21(DE3)

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