› 7ulv

X-ray diffraction
2.37Å resolution

Human DDAH1 soaked with its inactivator S-((4-chloropyridin-2-yl)methyl)-L-cysteine

Released:
DOI: 10.2210/pdb7ulv/pdb
PDB entry 7ulv coloured by chain, front view.
PDB entry 7ulv coloured by chain, side view.
PDB entry 7ulv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zheng Y, Butrin A, Tuley A, Liu D, Fast W

Function and Biology Details

Reaction catalysed: 
N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131736 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 308 amino acids
Theoretical weight: 33.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94760 (Residues: 1-285; Coverage: 100%)
Gene names: DDAH, DDAH1
Sequence domains: N,N dimethylarginine dimethylhydrolase, eukaryotic

Ligands and Environments

1 bound ligand:
Ligand NO6 6 x NO6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21
Unit cell:
a: 46.404Å b: 220.991Å c: 73.645Å
α: 90° β: 91.08° γ: 90°
R-values:
R R work R free
0.242 0.237 0.269
Expression system: Escherichia coli

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