Function and Biology

Human DNA polymerase eta-DNA-dGMPNPP ternary mismatch complex in 2.0 mM Mg2+ for 600s

Source organisms:
Biochemical function: damaged DNA binding
Biological process: DNA repair
Cellular component: not assigned

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF11799
Domain description: impB/mucB/samB family C-terminal domain
Occurring in:
  1. DNA polymerase eta
The deposited structure of PDB entry 7u7x contains 1 copy of Pfam domain PF11799 (impB/mucB/samB family C-terminal domain) in DNA polymerase eta. Showing 1 copy in chain A.

PF21704
Domain description: DNApol eta/Rev1, HhH motif
Occurring in:
  1. DNA polymerase eta
The deposited structure of PDB entry 7u7x contains 1 copy of Pfam domain PF21704 (DNApol eta/Rev1, HhH motif) in DNA polymerase eta. Showing 1 copy in chain A.

PF00817
Domain description: impB/mucB/samB family
Occurring in:
  1. DNA polymerase eta
The deposited structure of PDB entry 7u7x contains 1 copy of Pfam domain PF00817 (impB/mucB/samB family) in DNA polymerase eta. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036775
Domain description: DNA polymerase, Y-family, little finger domain superfamily
Occurring in:
  1. DNA polymerase eta
IPR001126
Domain description: UmuC domain
Occurring in:
  1. DNA polymerase eta
IPR043128
Domain description: Reverse transcriptase/Diguanylate cyclase domain
Occurring in:
  1. DNA polymerase eta
IPR017961
Domain description: DNA polymerase, Y-family, little finger domain
Occurring in:
  1. DNA polymerase eta
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA polymerase eta