› 7svo

X-ray diffraction
2.58Å resolution

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 8 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 903 amino acids
Theoretical weight: 103.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6V1X1 (Residues: 1-898; Coverage: 100%)
Gene names: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CW8 3 x CW8
Ligand TMO 11 x TMO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 162.816Å b: 246.016Å c: 261.767Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 0.208
Expression system: Spodoptera frugiperda

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Citations

1 review citation

Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution?
Deng et al. (2023)
3 other articles