› 7rsy

X-ray diffraction
2.7Å resolution

HIV-1 gp120 complex with CJF-III-049-R

Released:
DOI: 10.2210/pdb7rsy/pdb
PDB entry 7rsy coloured by chain, front view.
PDB entry 7rsy coloured by chain, side view.
PDB entry 7rsy coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.
Fritschi CJ, Liang S, Mohammadi M, Anang S, Moraca F, Chen J, Madani N, Sodroski JG, Abrams CF, Hendrickson WA, Smith AB
ACS Med Chem Lett 12 1824-1831 (2021)
PMID: 34795873

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168742 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HIV-1 gp120 Clade C1086 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 362 amino acids
Theoretical weight: 40.37 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand NAG 24 x NAG
Ligand 7IW 4 x 7IW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 71.577Å b: 120.754Å c: 195.277Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.279
Expression system: Homo sapiens

Quick links

Citations

4 citation in other articles

HIV-1 Vpu restricts Fc-mediated effector functions in vivo.
Prévost et al. (2022)
3 more