› 7loh

Solution NMR

Structure of the HIV-1 gp41 transmembrane domain and cytoplasmic tail

Released:
DOI: 10.2210/pdb7loh/pdb
PDB entry 7loh coloured by chain, ensemble of 15 models, front view.
PDB entry 7loh coloured by chain, ensemble of 15 models, side view.
PDB entry 7loh coloured by chain, ensemble of 15 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
NMR Model of the Entire Membrane-Interacting Region of the HIV-1 Fusion Protein and Its Perturbation of Membrane Morphology.
Piai A, Fu Q, Sharp AK, Bighi B, Brown AM, Chou JJ
J Am Chem Soc 143 6609-6615 (2021)
PMID: 33882664

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 180 amino acids
Theoretical weight: 20.85 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04578 (Residues: 677-856; Coverage: 22%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 8%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

3 citation in other articles

Fusion Peptide of SARS-CoV-2 Spike Rearranges into a Wedge Inserted in Bilayered Micelles.
Koppisetti et al. (2021)
2 more

2 mentions without citation

Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation.
Anokhin et al. (2022)
1 more