› 7c3k

X-ray diffraction
2.6Å resolution

Crystal Structure of mIRGB10

Released:
DOI: 10.2210/pdb7c3k/pdb
PDB entry 7c3k coloured by chain, front view.
PDB entry 7c3k coloured by chain, side view.
PDB entry 7c3k coloured by chain, top view.
Source organism: Mus musculus molossinus
Primary publication:
Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption.
Ha HJ, Chun HL, Lee SY, Jeong JH, Kim YG, Park HH
OpenAccess logo Commun Biol 4 92 (2021)
PMID: 33469160

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170937 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-gamma-inducible GTPase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 411 amino acids
Theoretical weight: 46.71 KDa
Source organism: Mus musculus molossinus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0GUM3 (Residues: 1-406; Coverage: 97%)
Gene names: Gm12250, Irgb10
Sequence domains: Interferon-inducible GTPase (IIGP)

Ligands and Environments

1 bound ligand:
Ligand GDP 2 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 62.51Å b: 63.19Å c: 117.92Å
α: 90° β: 98.7° γ: 90°
R-values:
R R work R free
0.213 0.213 0.272
Expression system: Escherichia coli

Quick links

Citations

1 review citation

How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens.
Dockterman et al. (2022)
2 other articles

2 mentions without citation

Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.
Saijo-Hamano et al. (2022)
1 more