› 7b3v

X-ray diffraction
1.93Å resolution

Crystal structure of c-MET bound by compound 3

Released:
DOI: 10.2210/pdb7b3v/pdb
PDB entry 7b3v coloured by chain, front view.
PDB entry 7b3v coloured by chain, side view.
PDB entry 7b3v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Collie GW, Michaelides IN, Embrey K, Stubbs CJ, Börjesson U, Dale IL, Snijder A, Barlind L, Song K, Khurana P, Phillips C, Storer RI
ACS Med Chem Lett 12 162-167 (2021)
PMID: 33488978

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 33.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08581 (Residues: 1049-1346; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand SWB 1 x SWB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 111.646Å b: 42.792Å c: 86.137Å
α: 90° β: 121.29° γ: 90°
R-values:
R R work R free
0.226 0.225 0.248
Expression system: Escherichia coli

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Citations

1 review citation

The Recycling of Substandard Rocket Fuel N,N-Dimethylhydrazine via the Involvement of Its Hydrazones Derived from Glyoxal, Acrolein, Metacrolein, Crotonaldehyde, and Formaldehyde in Organic Synthesis.
Ivanova et al. (2023)
6 other articles