› 7v3z

X-ray diffraction
3.29Å resolution

Structure of cannabinoid receptor type 1(CB1)

Released:
DOI: 10.2210/pdb7v3z/pdb
PDB entry 7v3z coloured by chain, front view.
PDB entry 7v3z coloured by chain, side view.
PDB entry 7v3z coloured by chain, top view.
Source organisms:
Primary publication:
A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.
Wang X, Liu D, Shen L, Li F, Li Y, Yang L, Xu T, Tao H, Yao D, Wu L, Hirata K, Bohn LM, Makriyannis A, Liu X, Hua T, Liu ZJ, Wang J
J Am Chem Soc 143 16320-16325 (2021)
PMID: 34596399

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cannabinoid receptor 1; Flavodoxin Chain: A
Molecule details ›
Chain: A
Length: 438 amino acids
Theoretical weight: 48.6 KDa
Source organisms: Expression system: Mammalian expression vector Flag-EGFP-MCS-pcDNA3.1
UniProt:
  • Canonical: P21554 (Residues: 102-306, 336-414; Coverage: 60%)
  • Canonical: P00323 (Residues: 3-148; Coverage: 99%)
Gene names: CNR, CNR1, DVU_2680
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 9GF 1 x 9GF
Ligand CLR 1 x CLR
Ligand FMN 1 x FMN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45XU
Unit cell:
a: 65.81Å b: 75.35Å c: 138.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.276
Expression system: Mammalian expression vector Flag-EGFP-MCS-pcDNA3.1

Quick links

Citations

7 review citations

AlphaFold 2 and NMR Spectroscopy: Partners to Understand Protein Structure, Dynamics and Function.
Laurents DV. (2022)
6 more

4 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
3 more