› 7n91

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase beta-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 340 amino acids
Theoretical weight: 38.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23443 (Residues: 82-421; Coverage: 65%)
Gene names: RPS6KB1, STK14A
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 1RJ 2 x 1RJ
2 modified residues:
Ligand TPO 2 x TPO
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 59.3Å b: 74.55Å c: 150.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.272
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Beyond controlling cell size: functional analyses of S6K in tumorigenesis.
Wu et al. (2022)
1 other article