› 7du9

X-ray diffraction
2.31Å resolution

Crystal structure of human Proto-oncogene tyrosine-protein kinase receptor Ret in complex with Pralsetinib

Released:
DOI: 10.2210/pdb7du9/pdb
PDB entry 7du9 coloured by chain, front view.
PDB entry 7du9 coloured by chain, side view.
PDB entry 7du9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Miyazaki I, Ishida K, Suzuki T

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble RET kinase fragment Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 35.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07949 (Residues: 705-1013; Coverage: 29%)
Gene names: CDHF12, CDHR16, PTC, RET
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand Q4J 2 x Q4J
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 50.887Å b: 80.577Å c: 79.866Å
α: 90° β: 99.72° γ: 90°
R-values:
R R work R free
0.22 0.219 0.249
Expression system: Spodoptera frugiperda

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