› 6yid

X-ray diffraction
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184950 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase ULK2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 280 amino acids
Theoretical weight: 31.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IYT8 (Residues: 1-276; Coverage: 27%)
Gene names: KIAA0623, ULK2
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand EDJ 4 x EDJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 75.968Å b: 76.526Å c: 95.244Å
α: 90° β: 97.03° γ: 90°
R-values:
R R work R free
0.194 0.192 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Regulated cell death (RCD) in cancer: key pathways and targeted therapies.
Peng et al. (2022)
10 more

2 mentions without citation

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Ren et al. (2020)
1 more