› 6x9h

X-ray diffraction
3.01Å resolution

Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1)

Released:
DOI: 10.2210/pdb6x9h/pdb
PDB entry 6x9h coloured by chain, front view.
PDB entry 6x9h coloured by chain, side view.
PDB entry 6x9h coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.
Liu Y, Ma J, DesJarlais RL, Hagan R, Rech J, Lin D, Liu C, Miller R, Schoellerman J, Luo J, Letavic M, Grasberger B, Maher M
Commun Biol 4 174 (2021)
PMID: 33564124

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 438 amino acids
Theoretical weight: 50.15 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q1XA76 (Residues: 26-463; Coverage: 83%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel

Ligands and Environments

3 bound ligands:
Ligand NAG 3 x NAG
Ligand UZG 3 x UZG
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 91.786Å b: 116.149Å c: 227.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.224 0.265
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Mango et al. (2021)
1 more

1 mention without citation

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.
Liu et al. (2021)