› 6pt3

X-ray diffraction
3.3Å resolution

Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287

Released:
DOI: 10.2210/pdb6pt3/pdb
PDB entry 6pt3 coloured by chain, front view.
PDB entry 6pt3 coloured by chain, side view.
PDB entry 6pt3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.
Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Müller CE, Stevens RC
OpenAccess logo Sci Adv 5 eaax9115 (2019)
PMID: 31807708

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Delta-type opioid receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 454 amino acids
Theoretical weight: 51.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41143 (Residues: 41-338; Coverage: 80%)
Gene names: OPRD, OPRD1
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
Ligand OWY 2 x OWY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 49.084Å b: 142.101Å c: 157.491Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.245 0.269
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Biased Opioid Ligands.
Faouzi et al. (2020)
13 more

15 mentions without citation

Immunomodulatory Role of Neuropeptides in the Cornea.
Puri et al. (2022)
14 more