› 6oim

X-ray diffraction
1.65Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase KRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 183 amino acids
Theoretical weight: 21.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Best match: P01116 (Residues: 1-169)
Gene names: KRAS, KRAS2, RASK2

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
Ligand MOV 1 x MOV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 40.868Å b: 58.417Å c: 65.884Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

316 review citations

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Koppula et al. (2021)
315 more

45 mentions without citation

RAS-targeted therapies: is the undruggable drugged?
Moore et al. (2020)
44 more