› 6mob

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 35.33 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P10721 (Residues: 566-693, 754-935; Coverage: 33%)
  • Best match: P10721-4 (Residues: 27-32, 35-216)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand NO3 14 x NO3
Ligand JWY 1 x JWY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P43212
Unit cell:
a: 80.699Å b: 80.699Å c: 145.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.21
Expression system: Trichoplusia ni

Quick links

Citations

37 review citations

Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.
Wu et al. (2022)
36 more

3 mentions without citation

An overview of kinase downregulators and recent advances in discovery approaches.
Wang et al. (2021)
2 more