Function and Biology

Crystal structure of catalytically inactive FnCas12a in complex with a crRNA guide and a dsDNA target

Source organisms:
Biochemical function: Bacillus subtilis ribonuclease activity
Biological process: defense response to virus
Cellular component: not assigned

EC 4.6.1.22: Bacillus subtilis ribonuclease

Reaction catalysed:
RNA = a 5'-hydroxy-ribonucleotide + n nucleoside-2',3'-cyclophosphates
Systematic name:
(RNA) 5'-hydroxy-ribonucleotide-3'-(RNA fragment)-lyase (cyclicizing; (RNA fragment)-3'- nucleoside -2',3'-cyclophosphate-forming)
Alternative Name(s):
  • Bacterial RNA lyase
  • Proteus mirabilis RNase
  • Ribonucleate nucleotido-2'-transferase (cyclizing)

EC 3.1.21.1: Deoxyribonuclease I

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products
Alternative Name(s):
  • Alkaline DNase
  • Alkaline deoxyribonuclease
  • DNA depolymerase
  • DNA endonuclease
  • DNA nuclease
  • DNAase
  • DNase
  • DNase I
  • Deoxyribonuclease (pancreatic)
  • Deoxyribonuclease A
  • Deoxyribonucleic phosphatase
  • Dornava
  • Dornavac
  • Endodeoxyribonuclease I
  • Escherichia coli endonuclease I
  • Pancreatic DNase
  • Pancreatic deoxyribonuclease
  • Pancreatic dornase
  • Thymonuclease
  • Thymonuclease, dornase

Sequence families

Pfam Protein families (Pfam)
PF18510
Domain description: Nuclease domain
Occurring in:
  1. CRISPR-associated endonuclease Cas12a
The deposited structure of PDB entry 6i1k contains 1 copy of Pfam domain PF18510 (Nuclease domain) in CRISPR-associated endonuclease Cas12a. Showing 1 copy in chain A.

PF18516
Domain description: RuvC nuclease domain
Occurring in:
  1. CRISPR-associated endonuclease Cas12a
The deposited structure of PDB entry 6i1k contains 1 copy of Pfam domain PF18516 (RuvC nuclease domain) in CRISPR-associated endonuclease Cas12a. Showing 1 copy in chain A.

PF18501
Domain description: Alpha helical recognition lobe domain
Occurring in:
  1. CRISPR-associated endonuclease Cas12a
The deposited structure of PDB entry 6i1k contains 1 copy of Pfam domain PF18501 (Alpha helical recognition lobe domain) in CRISPR-associated endonuclease Cas12a. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR040882
Domain description: Cas12a, nuclease domain
Occurring in:
  1. CRISPR-associated endonuclease Cas12a
IPR040852
Domain description: Cas12a, RuvC nuclease domain
Occurring in:
  1. CRISPR-associated endonuclease Cas12a
IPR040787
Domain description: Cas12a, REC1 domain
Occurring in:
  1. CRISPR-associated endonuclease Cas12a
IPR027620
Domain description: CRISPR-associated endonuclease Cas12a
Occurring in:
  1. CRISPR-associated endonuclease Cas12a