› 6ekn

X-ray diffraction
1.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage metalloelastase Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 17.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P39900 (Residues: 106-263)
Gene names: HME, MMP12

Ligands and Environments

4 bound ligands:
Ligand ZN 2 x ZN
Ligand CA 3 x CA
Ligand B9N 1 x B9N
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: C2
Unit cell:
a: 51.56Å b: 60.35Å c: 54.56Å
α: 90° β: 116.1° γ: 90°
R-values:
R R work R free
0.146 0.144 0.175
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Digestive Inflammation: Role of Proteolytic Dysregulation.
Mariaule et al. (2021)
3 more