› 6v6o

X-ray diffraction
2.1Å resolution

EGFR(T790M/V948R) in complex with LN2380

Released:
DOI: 10.2210/pdb6v6o/pdb
PDB entry 6v6o coloured by chain, front view.
PDB entry 6v6o coloured by chain, side view.
PDB entry 6v6o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.
Heppner DE, Günther M, Wittlinger F, Laufer SA, Eck MJ
J Med Chem 63 4293-4305 (2020)
PMID: 32243152

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 327 amino acids
Theoretical weight: 37.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 696-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand CL 8 x CL
Ligand QQM 8 x QQM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 71.55Å b: 102.36Å c: 173.569Å
α: 90° β: 101.3° γ: 90°
R-values:
R R work R free
0.196 0.195 0.221
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

A structural perspective on targeting the RTK/Ras/MAP kinase pathway in cancer.
Heppner et al. (2021)
1 more

5 mentions without citation

Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.
Heppner et al. (2020)
4 more