› 6cn9

X-ray diffraction
1.8Å resolution

Crystal structure of the Kinase domain of WNK1

Released:
DOI: 10.2210/pdb6cn9/pdb
PDB entry 6cn9 coloured by chain, front view.
PDB entry 6cn9 coloured by chain, side view.
PDB entry 6cn9 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Min X, Lee BH, Cobb MH, Goldsmith EJ
Structure 12 1303-11 (2004)
PMID: 15242606

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191605 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase WNK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 290 amino acids
Theoretical weight: 33.92 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JIH7 (Residues: 194-483; Coverage: 14%)
Gene names: Hsn2, Prkwnk1, Wnk1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 8 x GOL
Ligand SO4 1 x SO4
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 38.308Å b: 57.767Å c: 65.657Å
α: 91.32° β: 89.99° γ: 90.88°
R-values:
R R work R free
0.164 0.161 0.211
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Emerging roles of pseudokinases.
Boudeau et al. (2006)
51 more

6 mentions without citation

Recent applications of computational methods to allosteric drug discovery.
Govindaraj et al. (2022)
5 more