EC 3.4.11.2: Membrane alanyl aminopeptidase
Reaction catalysed:
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
Systematic name:
-
Alternative Name(s):
- Alanine aminopeptidase
- Alanine-specific aminopeptidase
- Alanyl aminopeptidase
- Amino-oligopeptidase
- Aminopeptidase M
- Aminopeptidase N
- CD13
- Cysteinylglycinase
- Cysteinylglycine dipeptidase
- L-alanine aminopeptidase
- Membrane alanine aminopeptidase
- Membrane aminopeptidase I
- Microsomal aminopeptidase
- Particle-bound aminopeptidase
- Peptidase E
- Pseudo leucine aminopeptidase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR001930
Domain description:
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Occurring in:
Occurring in:
IPR037144
Domain description:
Peptidase M1, alanyl aminopeptidase, C-terminal domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
1.25.50.10
Class:
Mainly Alpha
Architecture:
Alpha Horseshoe
Topology:
Zincin-like fold
Homology:
Peptidase M1, alanyl aminopeptidase, C-terminal domain
Occurring in:
2.60.40.1840
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Immunoglobulin-like
Occurring in:
1.10.390.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Neutral Protease; domain 2
Homology:
Neutral Protease Domain 2
Occurring in:
3.30.2010.30
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Zincin-like
Homology:
Zincin-like
Occurring in: