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Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH

Source organism: Burkholderia pseudomallei 1710b
Biochemical function: metal ion binding
Biological process: cellular oxidant detoxification
Cellular component: cytosol

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EC 1.11.1.21: Catalase peroxidase

Reaction catalysed:
2 H(2)O(2) = O(2) + 2 H(2)O
Systematic name:
Donor:hydrogen-peroxide oxidoreductase
Alternative Name(s):
  • KatG (gene name)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00141
Domain description: Peroxidase
Occurring in:
  1. Catalase-peroxidase
The deposited structure of PDB entry 5sxx contains 4 copies of Pfam domain PF00141 (Peroxidase) in Catalase-peroxidase. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR002016
Domain description: Haem peroxidase
Occurring in:
  1. Catalase-peroxidase
IPR000763
Domain description: Catalase-peroxidase haem
Occurring in:
  1. Catalase-peroxidase
IPR010255
Domain description: Haem peroxidase superfamily
Occurring in:
  1. Catalase-peroxidase
IPR019793
Domain description: Peroxidases heam-ligand binding site
Occurring in:
  1. Catalase-peroxidase
IPR019794
Domain description: Peroxidase, active site
Occurring in:
  1. Catalase-peroxidase

Structure domains

CATH CATH domains
1.10.520.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 1
Homology: Peroxidase; domain 1
Occurring in:
  1. Catalase-peroxidase
The deposited structure of PDB entry 5sxx contains 4 copies of CATH domain 1.10.520.10 (Peroxidase; domain 1) in Catalase-peroxidase. Showing 2 copies in chain A.
1.10.420.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 2
Homology: Peroxidase, domain 2
Occurring in:
  1. Catalase-peroxidase
The deposited structure of PDB entry 5sxx contains 4 copies of CATH domain 1.10.420.10 (Peroxidase; domain 2) in Catalase-peroxidase. Showing 2 copies in chain A.

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