› 5mcr

Solution NMR

Quadruplex with flipped tetrad formed by an artificial sequence

Released:
DOI: 10.2210/pdb5mcr/pdb
PDB entry 5mcr coloured by chain, ensemble of 10 models, front view.
PDB entry 5mcr coloured by chain, ensemble of 10 models, side view.
PDB entry 5mcr coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes.
Dickerhoff J, Haase L, Langel W, Weisz K
ACS Chem Biol 12 1308-1315 (2017)
PMID: 28318229

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-119014 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
Artificial quadruplex with propeller, diagonal and lateral loop Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 6.95 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand GF2 2 x GF2

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acidā»Protein Interaction.
Sun et al. (2019)
3 more