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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening

Source organism: Homo sapiens
Biochemical function: calcium-independent phospholipase A2 activity
Biological process: positive regulation of monocyte chemotaxis
Cellular component: high-density lipoprotein particle

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EC 3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase

Reaction catalysed:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate
Systematic name:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
Alternative Name(s):
  • 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase
  • 2-acetyl-1-alkylglycerophosphocholine esterase
  • Alkylacetyl-GPC:acetylhydrolase
  • LDL-PLA(2)
  • LDL-associated phospholipase A(2)
  • PAF 2-acylhydrolase
  • PAF acetylhydrolase
  • Platelet-activating factor acetylhydrolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03403
Domain description: Platelet-activating factor acetylhydrolase, isoform II
Occurring in:
  1. Platelet-activating factor acetylhydrolase
The deposited structure of PDB entry 5jan contains 1 copy of Pfam domain PF03403 (Platelet-activating factor acetylhydrolase, isoform II) in Platelet-activating factor acetylhydrolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Platelet-activating factor acetylhydrolase
IPR016715
Domain description: Platelet-activating factor acetylhydrolase-like, eukaryote
Occurring in:
  1. Platelet-activating factor acetylhydrolase

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Platelet-activating factor acetylhydrolase
The deposited structure of PDB entry 5jan contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Platelet-activating factor acetylhydrolase. Showing 1 copy in chain A.

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