PDBe 5k1i

X-ray diffraction
2.61Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 326 amino acids
Theoretical weight: 37.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08499 (Residues: 388-713; Coverage: 40%)
Gene names: DPDE3, PDE4D
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P1
Unit cell:
a: 61.444Å b: 78.347Å c: 161.756Å
α: 91.01° β: 92.79° γ: 90.08°
R-values:
R R work R free
0.195 0.191 0.258
Expression system: Escherichia coli BL21(DE3)