Function and Biology

Crystal structure of the ROQ domain of human Roquin-2

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF18386
Domain description: Roquin II domain
Occurring in:
  1. Roquin-2
The deposited structure of PDB entry 4z30 contains 1 copy of Pfam domain PF18386 (Roquin II domain) in Roquin-2. Showing 1 copy in chain A.

PF21206
Domain description: Roquin 1/2-like, ROQ domain
Occurring in:
  1. Roquin-2
The deposited structure of PDB entry 4z30 contains 1 copy of Pfam domain PF21206 (Roquin 1/2-like, ROQ domain) in Roquin-2. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR041523
Domain description: Roquin II
Occurring in:
  1. Roquin-2