X-ray diffraction
1.24Å resolution

Crystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)


Function and Biology Details

Reaction catalysed:
Glutamyl endopeptidase. Bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
A disintegrin and metalloproteinase with thrombospondin motifs 4 Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 25.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: O75173 (Residues: 213-439; Coverage: 29%)
Gene names: ADAMTS4, KIAA0688, UNQ769/PRO1563
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 40.506Å b: 67.923Å c: 74.581Å
α: 90° β: 90° γ: 90°
R R work R free
0.196 0.196 0.213
Expression system: Homo sapiens