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Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides.

Choo JA, Thong SY, Yap J, van Esch WJ, Raida M, Meijers R, Lescar J, Verhelst SH, Grotenbreg GM
Angew Chem Int Ed Engl 53 13390-4 (2014)
Cited: 15 times
EuropePMC logo PMID: 25348595

Abstract

Bioorthogonal cleavable linkers are attractive building blocks for compounds that can be manipulated to study biological and cellular processes. Sodium dithionite sensitive azobenzene-containing (Abc) peptides were applied for the temporary stabilization of recombinant MHC complexes, which can then be employed to generate libraries of MHC tetramers after exchange with a novel epitope. This technology represents an important tool for high-throughput studies of disease-specific T cell responses.

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  1. Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics Approach. Abdelmageed MI, Abdelmoneim AH, Mustafa MI, Elfadol NM, Murshed NS, Shantier SW, Makhawi AM. Biomed Res Int 2020 2683286 (2020)
  2. In Silico Analysis of Epitope-Based Vaccine Candidates against Hepatitis B Virus Polymerase Protein. Zheng J, Lin X, Wang X, Zheng L, Lan S, Jin S, Ou Z, Wu J. Viruses 9 E112 (2017)
  3. A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells. Luimstra JJ, Garstka MA, Roex MCJ, Redeker A, Janssen GMC, van Veelen PA, Arens R, Falkenburg JHF, Neefjes J, Ovaa H. J Exp Med 215 1493-1504 (2018)
  4. Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities. Lai J, Tan WJ, Too CT, Choo JA, Wong LH, Mustafa FB, Srinivasan N, Lim AP, Zhong Y, Gascoigne NR, Hanson BJ, Chan SH, Chen J, MacAry PA. Blood 128 1396-1407 (2016)
  5. Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance. Rosendahl Huber SK, Luimstra JJ, van Beek J, Hoppes R, Jacobi RH, Hendriks M, Kapteijn K, Ouwerkerk C, Rodenko B, Ovaa H, de Jonge J. PLoS One 11 e0156462 (2016)
  6. TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants. Lai J, Choo JAL, Tan WJ, Too CT, Oo MZ, Suter MA, Mustafa FB, Srinivasan N, Chan CEZ, Lim AGX, Zhong Y, Chan SH, Hanson BJ, Gascoigne NRJ, MacAry PA. Sci Rep 7 9923 (2017)
  7. Epitope-Based Peptide Vaccine against Glycoprotein G of Nipah Henipavirus Using Immunoinformatics Approaches. Mohammed AA, Shantier SW, Mustafa MI, Osman HK, Elmansi HE, Osman IA, Mohammed RA, Abdelrhman FA, Elnnewery ME, Yousif EM, Mustafa MM, Elfadol NM, Abdalla AI, Mahmoud E, Yagaub AA, Ahmed YA, Hassan MA. J Immunol Res 2020 2567957 (2020)
  8. Immunoinformatics prediction of potential B-cell and T-cell epitopes as effective vaccine candidates for eliciting immunogenic responses against Epstein-Barr virus. Olotu FA, Soliman MES. Biomed J 44 317-337 (2021)
  9. Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model. Wu L, Brzostek J, Sankaran S, Wei Q, Yap J, Tan TYY, Lai J, MacAry PA, Gascoigne NRJ. Cancers (Basel) 13 867 (2021)
  10. Epitope-Based Peptide Vaccine Against Fructose-Bisphosphate Aldolase of Madurella mycetomatis Using Immunoinformatics Approaches. Mohammed AA, ALnaby AM, Sabeel SM, AbdElmarouf FM, Dirar AI, Ali MM, Khandgawi MA, Yousif AM, Abdulgadir EM, Sabahalkhair MA, Abbas AE, Hassan MA. Bioinform Biol Insights 12 1177932218809703 (2018)
  11. Production and Thermal Exchange of Conditional Peptide-MHC I Multimers. Luimstra JJ, Franken KLMC, Garstka MA, Drijfhout JW, Neefjes J, Ovaa H. Curr Protoc Immunol 126 e85 (2019)
  12. Design of an Epitope-Based Peptide Vaccine Against the Major Allergen Amb a 11 Using Immunoinformatic Approaches. Moten D, Kolchakova D, Todorov K, Mladenova T, Dzhambazov B. Protein J 41 315-326 (2022)
  13. CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance. Wu L, Brzostek J, Sakthi Vale PD, Wei Q, Koh CKT, Ong JXH, Wu LZ, Tan JC, Chua YL, Yap J, Song Y, Tan VJY, Tan TYY, Lai J, MacAry PA, Gascoigne NRJ. Cell Rep Med 4 100917 (2023)
  14. Development a novel multiepitope DNA vaccine against human SARS coronavirus-2: an immunoinformatic designing study. Nemati AS, Mirzaie S, Masoumian MR, Sheikhi F, Jamalan M. Turk J Biol 46 263-276 (2022)


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