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Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells.

Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ
Immunity 39 1032-42 (2013)
Related entries: 4mng, 4mnh, 4ndm

Cited: 150 times
EuropePMC logo PMID: 24239091

Abstract

The nature of the antigens recognized by γδ T cells and their potential recognition of major histocompatibility complex (MHC)-like molecules has remained unclear. Members of the CD1 family of lipid-presenting molecules are suggested ligands for Vδ1 TCR-expressing γδ T cells, the major γδ lymphocyte population in epithelial tissues. We crystallized a Vδ1 TCR in complex with CD1d and the self-lipid sulfatide, revealing the unusual recognition of CD1d by germline Vδ1 residues spanning all complementarity-determining region (CDR) loops, as well as sulfatide recognition separately encoded by nongermline CDR3δ residues. Binding and functional analysis showed that CD1d presenting self-lipids, including sulfatide, was widely recognized by gut Vδ1+ γδ T cells. These findings provide structural demonstration of MHC-like recognition of a self-lipid by γδ T cells and reveal the prevalence of lipid recognition by innate-like T cell populations.

Reviews - 4mq7 mentioned but not cited (1)

  1. The T cell antigen receptor: the Swiss army knife of the immune system. Attaf M, Legut M, Cole DK, Sewell AK. Clin Exp Immunol 181 1-18 (2015)

Articles - 4mq7 mentioned but not cited (3)

  1. Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells. Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Immunity 39 1032-1042 (2013)
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  3. Diversification of CD1 Molecules Shapes Lipid Antigen Selectivity. Paterson NM, Al-Zubieri H, Barber MF. Mol Biol Evol 38 2273-2284 (2021)


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