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Crystal structure of human alpha tubulin acetyltransferase catalytic domain

Source organism: Homo sapiens
Biochemical function: tubulin N-acetyltransferase activity
Biological process: alpha-tubulin acetylation
Cellular component: microtubule

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EC 2.3.1.108: Alpha-tubulin N-acetyltransferase

Reaction catalysed:
Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[alpha-tubulin]-L-lysine N(6)-acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase
  • Acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase
  • Alpha-tubulin acetylase
  • Alpha-tubulin acetyltransferase
  • TAT
  • Tubulin N-acetyltransferase
  • Tubulin acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF05301
Domain description: GNAT acetyltransferase, Mec-17
Occurring in:
  1. Alpha-tubulin N-acetyltransferase 1
The deposited structure of PDB entry 4b5o contains 1 copy of Pfam domain PF05301 (GNAT acetyltransferase, Mec-17 ) in Alpha-tubulin N-acetyltransferase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR007965
Domain description: Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type
Occurring in:
  1. Alpha-tubulin N-acetyltransferase 1
IPR016181
Domain description: Acyl-CoA N-acyltransferase
Occurring in:
  1. Alpha-tubulin N-acetyltransferase 1
IPR038746
Domain description: Alpha-tubulin N-acetyltransferase
Occurring in:
  1. Alpha-tubulin N-acetyltransferase 1

Structure domain

CATH CATH domain
3.40.630.30
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Aminopeptidase
Occurring in:
  1. Alpha-tubulin N-acetyltransferase 1
The deposited structure of PDB entry 4b5o contains 1 copy of CATH domain 3.40.630.30 (Aminopeptidase) in Alpha-tubulin N-acetyltransferase 1. Showing 1 copy in chain A.

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