› › Function and Biology

STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH THE PYRIDINE INHIBITOR N-(1-(5-(trifluoromethyl)(pyridin-2-yl)) piperidin-4yl)-N-(4-(trifluoromethyl)phenyl)pyridin-3-amine (EPL- BS967, UDD)

Source organism: Trypanosoma cruzi
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 1.14.14.154: Sterol 14-alpha-demethylase

Reaction catalysed:
(1a) a 14-alpha-methylsteroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 14-alpha-hydroxysteroid + [oxidized NADPH--hemoprotein reductase] + H(2)O
Systematic name:
Sterol,[reduced NADPH--hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)
Alternative Name(s):
  • CYP51
  • Cytochrome P450 51
  • ERG11
  • Lanosterol 14-alpha-demethylase
  • Lanosterol 14-demethylase
  • Obtusufoliol 14-demethylase
  • Sterol 14-demethylase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00067
Domain description: Cytochrome P450
Occurring in:
  1. Sterol 14-alpha demethylase
The deposited structure of PDB entry 3zg3 contains 1 copy of Pfam domain PF00067 (Cytochrome P450) in Sterol 14-alpha demethylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001128
Domain description: Cytochrome P450
Occurring in:
  1. Sterol 14-alpha demethylase
IPR002403
Domain description: Cytochrome P450, E-class, group IV
Occurring in:
  1. Sterol 14-alpha demethylase
IPR036396
Domain description: Cytochrome P450 superfamily
Occurring in:
  1. Sterol 14-alpha demethylase
IPR017972
Domain description: Cytochrome P450, conserved site
Occurring in:
  1. Sterol 14-alpha demethylase

Structure domain

CATH CATH domain
1.10.630.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cytochrome p450
Homology: Cytochrome P450
Occurring in:
  1. Sterol 14-alpha demethylase
The deposited structure of PDB entry 3zg3 contains 1 copy of CATH domain 1.10.630.10 (Cytochrome p450) in Sterol 14-alpha demethylase. Showing 1 copy in chain A.

Quick links