X-ray diffraction
3.4Å resolution

Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1)

Source organism: Homo sapiens
Primary publication:
Crystal structure of the human two-pore domain potassium channel K2P1.
Science 335 432-6 (2012)
PMID: 22282804

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Potassium channel subfamily K member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 280 amino acids
Theoretical weight: 31.91 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: O00180 (Residues: 19-288; Coverage: 80%)
Gene names: HOHO1, KCNK1, KCNO1, TWIK1
Structure domains: Helix Hairpins

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 82.08Å b: 123.171Å c: 119.305Å
α: 90° β: 94.91° γ: 90°
R R work R free
0.273 0.273 0.279
Expression system: Komagataella pastoris