EC 2.4.2.30: NAD(+) ADP-ribosyltransferase
Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Systematic name:
NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Alternative Name(s):
- ADP-ribosyltransferase (polymerizing)
- NAD(+):poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- Poly(ADP-ribose) synthase
- Poly(ADP-ribose) synthetase
- Poly(ADP-ribose)polymerase
- Poly(adenosine diphosphate ribose) polymerase
GO terms
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Protein family (Pfam)![The deposited structure of PDB entry 3tws contains 8 copies of Pfam domain PF12796 (Ankyrin repeats (3 copies)) in Poly [ADP-ribose] polymerase tankyrase-2. Showing 2 copies in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3tws_1_A_Pfam_PF12796_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3tws</span> contains 8 copies of Pfam domain <span class='highlight'>PF12796 (Ankyrin repeats (3 copies))</span> in <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Showing 2 copies in chain <span class='highlight'>A</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 3tws contains 4 copies of CATH domain 1.25.40.20 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Poly [ADP-ribose] polymerase tankyrase-2. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3tws_1_A_CATH_1.25.40.20_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3tws</span> contains 4 copies of CATH domain <span class='highlight'>1.25.40.20 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")