3p91 › Citations

Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon.

Cardona-Felix CS, Lara-Gonzalez S, Brieba LG
Acta Crystallogr D Biol Crystallogr 67 497-505 (2011)
Cited: 9 times
EuropePMC logo PMID: 21636889

Abstract

Proliferating cellular nuclear antigen (PCNA) is a toroidal-shaped protein that is involved in cell-cycle control, DNA replication and DNA repair. Parasitic protozoa are early-diverged eukaryotes that are responsible for neglected diseases. In this work, a PCNA from a parasitic protozoon was identified, cloned and biochemically characterized and its crystal structure was determined. Structural and biochemical studies demonstrate that PCNA from Entamoeba histolytica assembles as a homotrimer that is able to interact with and stimulate the activity of a PCNA-interacting peptide-motif protein from E. histolytica, EhDNAligI. The data indicate a conservation of the biochemical mechanisms of PCNA-mediated interactions between metazoa, yeast and parasitic protozoa.

Articles - 3p91 mentioned but not cited (1)

  1. The E301R protein of African swine fever virus functions as a sliding clamp involved in viral genome replication. Li S, Ge H, Li Y, Zhang K, Yu S, Cao H, Wang Y, Deng H, Li J, Dai J, Li L-F, Luo Y, Sun Y, Geng Z, Dong Y, Zhang H, Qiu H-J. mBio 14 e0164523 (2023)


Reviews citing this publication (1)

  1. Episomal and chromosomal DNA replication and recombination in Entamoeba histolytica. Bhattacharya S. Front Mol Biosci 10 1212082 (2023)

Articles citing this publication (7)

  1. Crystal structure of the shrimp proliferating cell nuclear antigen: structural complementarity with WSSV DNA polymerase PIP-box. Carrasco-Miranda JS, Lopez-Zavala AA, Arvizu-Flores AA, Garcia-Orozco KD, Stojanoff V, Rudiño-Piñera E, Brieba LG, Sotelo-Mundo RR. PLoS One 9 e94369 (2014)
  2. A transposon-derived DNA polymerase from Entamoeba histolytica displays intrinsic strand displacement, processivity and lesion bypass. Pastor-Palacios G, López-Ramírez V, Cardona-Felix CS, Brieba LG. PLoS One 7 e49964 (2012)
  3. Identification of host cellular proteins that interact with the M protein of a highly pathogenic porcine reproductive and respiratory syndrome virus vaccine strain. Wang Q, Li Y, Dong H, Wang L, Peng J, An T, Yang X, Tian Z, Cai X. Virol J 14 39 (2017)
  4. Putrescine-dependent re-localization of TvCP39, a cysteine proteinase involved in Trichomonas vaginalis cytotoxicity. Carvajal-Gamez BI, Quintas-Granados LI, Arroyo R, Vázquez-Carrillo LI, Ramón-Luing Lde L, Carrillo-Tapia E, Alvarez-Sánchez ME. PLoS One 9 e107293 (2014)
  5. Epithelial Cells Expressing EhADH, An Entamoeba histolytica Adhesin, Exhibit Increased Tight Junction Proteins. Betanzos A, Zanatta D, Bañuelos C, Hernández-Nava E, Cuellar P, Orozco E. Front Cell Infect Microbiol 8 340 (2018)
  6. Proliferating cell nuclear antigen restores the enzymatic activity of a DNA ligase I deficient in DNA binding. Trasviña-Arenas CH, Cardona-Felix CS, Azuara-Liceaga E, Díaz-Quezada C, Brieba LG. FEBS Open Bio 7 659-674 (2017)
  7. The Sole DNA Ligase in Entamoeba histolytica Is a High-Fidelity DNA Ligase Involved in DNA Damage Repair. Azuara-Liceaga E, Betanzos A, Cardona-Felix CS, Castañeda-Ortiz EJ, Cárdenas H, Cárdenas-Guerra RE, Pastor-Palacios G, García-Rivera G, Hernández-Álvarez D, Trasviña-Arenas CH, Diaz-Quezada C, Orozco E, Brieba LG. Front Cell Infect Microbiol 8 214 (2018)


Quick links