› › Function and Biology

Crystal structure of the TRAF1:TRAF2:cIAP2 complex

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF16673
Domain description: TNF receptor-associated factor BIRC3 binding domain
Occurring in:
  1. TNF receptor-associated factor 2
  2. TNF receptor-associated factor 1
The deposited structure of PDB entry 3m0d contains 2 copies of Pfam domain PF16673 (TNF receptor-associated factor BIRC3 binding domain) in TNF receptor-associated factor 2. Showing 1 copy in chain A.
The deposited structure of PDB entry 3m0d contains 1 copy of Pfam domain PF16673 (TNF receptor-associated factor BIRC3 binding domain) in TNF receptor-associated factor 1. Showing 1 copy in chain C.

PF00653
Domain description: Inhibitor of Apoptosis domain
Occurring in:
  1. Baculoviral IAP repeat-containing protein 3
The deposited structure of PDB entry 3m0d contains 1 copy of Pfam domain PF00653 (Inhibitor of Apoptosis domain) in Baculoviral IAP repeat-containing protein 3. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR001370
Domain description: BIR repeat
Occurring in:
  1. Baculoviral IAP repeat-containing protein 3
IPR032070
Domain description: TNF receptor-associated factor, BIRC3 binding domain
Occurring in:
  1. TNF receptor-associated factor 2
  2. TNF receptor-associated factor 1

Structure domains

CATH CATH domains
1.20.5.170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. TNF receptor-associated factor 2
The deposited structure of PDB entry 3m0d contains 2 copies of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in TNF receptor-associated factor 2. Showing 1 copy in chain A.
1.10.1170.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Homology: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Occurring in:
  1. Baculoviral IAP repeat-containing protein 3
The deposited structure of PDB entry 3m0d contains 1 copy of CATH domain 1.10.1170.10 (Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A) in Baculoviral IAP repeat-containing protein 3. Showing 1 copy in chain D.
1.20.5.110
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. TNF receptor-associated factor 1
The deposited structure of PDB entry 3m0d contains 1 copy of CATH domain 1.20.5.110 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in TNF receptor-associated factor 1. Showing 1 copy in chain C.

Quick links